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INR (International Normalized Ratio)

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Uvod
Odnos izmjerenog PV (protrombinskog vemena) prema PV kontrolne plazme naziva se INR (International Normalized Ratio). PV odražava aktivnost faktora zgrušavanja vanjskog puta zgrušavanja, posebno faktora II, V, VII i X, i njihovu sposobnost stvaranja fibrina iz fibrinogena pod uticajem trombina.

Preporuka za INR rangove:
Stanje                                                                                                      INR rang
Tromboza proksimalne duboke vene (Proximal deep vein thrombosis)         2-3
Plućna embolija (Pulmonary embolism)                                                      2-3
Prolazni ishemični napadi (Transient ischemic attacks)                             2-3
Fibrilacija atrija-pretkomora (Atrial fibrillation)                                             2-3
Mehaničke protetske valvule (Mechanical prosthetic valves)                     3-4.5
Povratna venozna tromboembolička bolest (Recurrent venous thromboembolic disease)                                                                                                            3-4.5

Literatura:
Barbara A. Bullock, Reet L. Henze, Focus on Pathophysiology
Drew Provan: Clinical and Laboratory Investigation (Oxford Handbook)
Ravel R.: Clinical Laboratory Medicine, Mosby
Samir P. Desai, MD: Clinical's guide to Laboratory Medicine
Topić Elizabeta, Primorac Dragan, Janković Stipan: Medicinskobiokemijska dijagnostika u praksi
 

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