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ELEKTROFOREZA PROTEINA (Protein Electrophoresis, serum)

• Uvod • Uzroci povišenih vrijednosti • Uzroci sniženih vrijednosti • Literatura

Uvod
Normalan nalaz:
Albumini: 60% do 75% (0.6-0.75) [CF: 0.01; SM1: 0.01]
α-1: 1.7% do   5%   (0.02-0.05)
α-2: 6.7% do 12.5% (0.07-0.13)
β:    8.3% do 16.3% (0.08-0.16)
γ:   10.7% do 20% (0.11-0.2)

Albumin: 3.6-5.2 g/dl (36-52 g/L) [CF: 0.01; SMI: 1 g/L]
α-1: 0.1-0.4 g/dl (I-4 g/L)
α-2: 0.4-1 g/dl (4-10 g/L)
β: 0.5-1.2 g/dl (5-12 g/L)
γ: 0.6-1.6 g/dl (6-16 g/L)
Uzroci povišenih vrijednosti:
Albumini:
1.         dehidracija (dehydration)
α-1:
1.         Neoplastične bolesti (neoplastic diseases)
2.         Upale (inflammation)
α -2:
1.         Neoplazme (neoplasms)
2.         Upale (inflammation)
3.         Infekcije (infection)
4.         Nefrotski sindrom (nephrotic syndrome)
β:
1.         Hipotiroidizam (hypothyroidism)
2.         Bilijarna ciroza (biliary cirrhosis)
3.         Šećerna bolest (diabetes mellitus)
Uzroci sniženih vrijednosti:
Albumini:
1.         Malnutricija (malnutrition)
2.         Hronična bolest jetre (chronic liver disease)
3.         Malapsorpcija (malabsorption)
4.         Nefrotski sindrom (nephrotic syndrome)
5.         Opekotine (burns)
6.         Sistemski lupus eritematodes (SLE)

α-1:
1.         Emfizem: nedostatak α-1 antitripsina
2.         Nefroza (nephrosis)

α -2:
1.         Hemolitična anemija: pad haptoglobina
2.         Teška hepatocelularna oštećenja (severe hepatocellular damage)

β:         hypocholesterolemia, nephrosis

Literatura:
Barbara A. Bullock, Reet L. Henze, Focus on Pathophysiology
Drew Provan: Clinical and Laboratory Investigation (Oxford Handbook)
Ravel R.: Clinical Laboratory Medicine, Mosby
Samir P. Desai, MD: Clinical's guide to Laboratory Medicine
Topić Elizabeta, Primorac Dragan, Janković Stipan: Medicinskobiokemijska dijagnostika u praksi
 

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Home Laboratorij ELEKTROFOREZA PROTEINA (Protein Electrophoresis, serum)